ACE Gene mutation

ACE gene mutation

What is an ACE gene?

ACE stands for “angiotensin 1 converting enzyme, this protein regulation the balance of fluids and salts in the body.  ACE also stimulates the production of the hormone aldosterone whih is a home that triggers the absorption of salt and water by the kidneys.

ACE causes the activity of the conversion via its enzyme of angiotensin 1 to angiotensin 2.  This enzyme is involved in blood pressure regulation and electrolyte balance.

It catalyzes the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This angiotensin-converting enzyme (ACE) also inactivates the vasodilator protein, bradykinin. Accordingly, the encoded enzyme increases blood pressure.

ACE symptoms

Because ACE controls fluid and electrolyte balance, symptoms of an ACE mutation can be very wide-ranging and lead to many serious health problems.  Often many people with ACE problems are taking medications to prevent diseases including cardiovascular pathophysiologies (heart dysfunction and its associated characteristics (hypertrophy, cardiomyopathy and failure); vascular dysfunction and disease; ischemic heart disease), psoriasis, renal disease, stroke, and Alzheimer’s disease.

The following symptoms can be associated with ACE mutations:

  • Hypertension / Hypertensive events
  • Elevated blood pressure
  • Headaches
  • Heart disease / Heart attack
  • Kidney disease
  • Stroke
  • Alzheimer’s disease
  • Human coronaviruses, including SARS-CoV and SARS-CoV-2
  • Psoriasis
  • Infertility
  • Body fluid imbalances
  • Blood pressure problems including imbalances (low and high)
  • Inability to calm down your blood pressure from everyday emotional events such as stress

Imbalances of electrolytes such as:

Symptoms of essential electrolyte imbalances


  • Dizziness
  • Heat exhaustion
  • Low blood pressure
  • Rapid pulse
  • Mental apathy
  • Loss of appetite
  • Muscle cramps
  • Nausea
  • Vomiting
  • Reduced body weight
  • Headaches


  • Rapid irregular heartbeat
  • Muscle weakness
  • Pins and needles
  • Irritability
  • Nausea
  • Vomiting
  • Diarrhea
  • Swollen abdomen
  • Cellulite
  • Low blood pressure resulting from an imbalance of potassium: sodium ratio
  • Confusion
  • Mental apathy


  • Muscle tremors or spasms
  • Muscle weakness
  • Insomnia or nervousness
  • High blood pressure
  • Irregular heartbeat
  • Constipation
  • Fits or convulsions
  • Hyperactivity
  • Depression
  • Confusion
  • Lack of appetite
  • Calcium deposits in soft tissue e.g. kidney stones
  • Low levels of magnesium are also associated with increased rates of heart attack, anxiety, and nervousness

As you can see ACE gene mutations can cause many symptoms and also lead to many diseases.  Here is what they may look like, homozygous (double bad copies in red):

ACE mutation homozygous example

Treating ACE gene mutations

If you have ACE gene mutations regardless of them being homozygous or heterozygous, you must treat any active mutations to prevent serious health problems.  The good news is that these mutations are treatable. However it is important to do it right using experienced health practitioners. Those who understand the complicated nature of treating ACE gene mutations.

Get a consultation about your ACE mutations from the following link  ACE help.