AGT gene mutations

AGT gene mutation

The AGT gene is also called “angiotensinogen”, this gene is responsible for keeping essential electrolytes in balance.  AGT genes can cause imbalances in these electrolytes that can lead to serious health problems, even conditions such as:

  • Essential hypertension
  • Hypertension
  • Preeclampsia
  • Acute coronary artery syndrome
  • Coronary artery disease
  • Stroke
  • Heart attack
  • Type 2 diabetes
  • Left ventricular hypertrophy
  • Myocardial infarction
  • Peptic ulcer hemorrhage

AGT genes are regulators of:

  • Blood pressure
  • Body fluid
  • Electrolyte homeostasis

Symptoms of essential electrolytes imbalances


  • Dizziness
  • Heat exhaustion
  • Low blood pressure
  • Rapid pulse
  • Mental apathy
  • Loss of appetite
  • Muscle cramps
  • Nausea
  • Vomiting
  • Reduced body weight
  • Headaches


  • Rapid irregular heartbeat
  • Muscle weakness
  • Pins and needles
  • Irritability
  • Nausea
  • Vomiting
  • Diarrhea
  • Swollen abdomen
  • Cellulite
  • Low blood pressure resulting from an imbalance of potassium: sodium ratio
  • Confusion
  • Mental apathy


  • Muscle tremors or spasms
  • Muscle weakness
  • Insomnia or nervousness
  • High blood pressure
  • Irregular heartbeat
  • Constipation
  • Fits or convulsions
  • Hyperactivity
  • Depression
  • Confusion
  • Lack of appetite
  • Calcium deposits in soft tissue e.g. kidney stones
  • Low levels of magnesium are also associated with increased rates of heart attack, anxiety, and nervousness

As you can see AGT gene mutations can cause many symptoms and also lead to many diseases.  Here is what they may look like, homozygous (double bad copies in red), heterozygous (1 half a bad copy in yellow):

AGT genes