DHFR gene mutation

DHFR gene

The DHFR gene is part of the folate family of genes, this means DHFR works to process folate that gets delivered through the MTHFR gene.  The DHFR gene is also connected directly to the Biopterin cycle so it can affect both physical and mental health.

Once the folates pass through the FOLR genes (folate receptor genes), folates get converted to Dihydrofolate (DHF) via the DHFR genes (in Red) above.

In addition, the gene DHFR, which is part of the folate family of genes (MTHFR), is directly connected to the folate receptor, that feeds the biopterin cycle in your brain.

When the folate receptor is compromised (as per the image below showing homozygous or double copies of the DHFR gene mutation) and the DHFR has mutations and or is compromised with folic acid, ECGC, GSE and or radiation, the side effect is the disruption of making biopterin and neurotransmitters properly, essential blocking the ability to feeling happy and healthy mentally.

DHFR homozygous gene example

Becuase the DHFR gene works directly in the folate process, symptoms of a compromised or gene mutation in DHFR can look like a MTHFR gene problem or a folate deficiency as per the following symptoms:

Folate (vitamin B9) deficiency or DHFR gene mutation symptoms

  • Addictive behaviors
  • Alcoholism
  • Allergies
  • Alzheimer’s
  • Anxiety
  • Autism
  • Autism
  • Bipolar
  • Cancer
  • Cardiovascular disease – Heart attack, atherosclerosis, elevated cholesterol, hypertension,
    stroke, fat metabolism issues
  • Chemical sensitivity
  • Chronic fatigue syndrome
  • Chronic viral infection
  • Cleft palate
  • Congenital Heart defects
  • Depression
  • Diabetes
  • Downs syndrome
  • Fibromyalgia
  • Immune deficiency
  • Infertility
  • Insomnia
  • MS (multiple sclerosis)
  • Neural tube defects
  • Neuropathy
  • Nutritional disorders (Vitamin & mineral imbalances that lead to disease)
  • Panic attacks
  • Parkinsons
  • Pulmonary embolisms
  • Recurrent miscarriage
  • Schizophrenia
  • Spina bifida
  • Electromagnetic sensitivity
  • Thyroid dysfunction

As you can see this one gene mutation can cause serious health problems, but it doesn’t stop there.  When you have a nutritional break in folate due to DHFR gene mutations, the bigger problem is that folate works with all other B complex vitamins.

As you can imagine, just having active gene mutations in DHFR can lead to a cascade of nutritional breaks in all B complex vitamins and it gets more complex, this is because B complex vitamins work with hundreds of other biochemical reactions in the body and brain.

DHFR and radiation

The DHFR gene is also susceptible to EMF radiation which is now 100 million times more prevalent today than just 100 years ago, this means that many people now have problems processing their folate through the DHFR gene, which has led to many mental health problems.