FUT2 gene mutations

What is a FUT2 gene?

A Fut2 gene is a gene that gives instructions for making a protein called glycosylation. But it is also involved in the creation of the precursor of the H antigen which is crucial in maintaining good gut health. As well as producing important enzymes. However which are also needed to produce a healthy environment, for the production of healthy gut flora.

Problem FUT2 genes

FUT2: The 3 major FUT2 genes that seem to cause major problems for people are FUT2 A12190G, FUT2 G12447A, and FUT2 G12758A. The below example shows three SNPs that are homozygous, often these people cannot make H antigen and are at risk of serious disease.

It is also not uncommon for people that have heterozygous mutations in FUT2 to also have gut related health problems.

If you see any of these 3 FUT2 homozygous mutations you could be in serious trouble:

FUT2 homozygous mutations

Do you have FUT2 symptoms?

FUT2 is an extremely important gene. Moreover having a mutation in these genes can lead to literally thousands of health problems. Here are just some of the major symptoms to look out for:

  • Any Autoimmune disease
  • Leaky Gut
  • Intestinal permeability
  • Crohn’s disease
  • Ulcerative colitis
  • Eczema or dermatitis
  • Problems with IgG immunity
  • Problems with IgA immunity
  • Autism
  • IBS (Irritable Bowel Syndrome)
  • Pernicious anemia
  • Cardiovascular disease
  • Cancer
  • Neurodegenerative disorders
  • Gut flora imbalances
  • Mouth oversensitive to heat or cold
  • Irritability
  • Anxiety and or tension
  • Lack of energy
  • Constipation
  • Tender or sore muscles
  • Pale skin
  • Tooth decay
  • SIBO

Why is H antigen important?

The specificity of the H antigen is determined by the sequence of oligosaccharides. Almost everyone to date who has been diagnosed with ulcerative colitis and Crohn’s disease are homozygous for FUT2 mutations. This combination of genes also play a large role in Autism. FUT2 gene mutations can cause dysfunctional vitamin B12 absorption (Vitamin b12 plasma level quantitative trait locus 1).

FUT2 is involved in protein glycosylation. It means you can lose your ability to properly hold good bacteria in the gut leading to microbiome dysbiosis which can lead to serious diseases both physically and or mentally.

Problem FUT2 genes

If you are lacking the ability to produce H antigen in the gut. In short, your probiotics (good bacteria) will not have anything to stick to in the gut. Which leads to serious gut health problems. This often leads to a risk factor for leaky gut and autoimmune disease.

One of the biggest problems with these gene mutations is overall nutritional disorders. This is a factor most often overlooked by many health practitioners.

Another thing that we see quite often in these homozygous FUT2’s is hyperoxaluria, which can result in lowered ability to defend against some cancers. One of the first problems found with active FUT2 mutations is inflammation of the gut which is almost impossible to resolve with restoring H antigen production.

Since poor producers of H antigen already have poor gut health due to poor gut bacteria and or microbiome dysbiosis this makes these people more susceptible to the destruction of the intestinal lining or mucosa especially the shikimate pathway of our gut microbiome. Because of their lack of prebiotic production, It is obvious that GMO’d Roundup ready glyphosate foods increase their risk of disease by loss of intestinal mucosa (leaky gut).

FUT2 Secretors VS Non-Sectors

Some of us carry the ability to be a “secretor”. This means having the ability to secrete our blood type antigen in secretions.  Some of us are “non -secretors” which lack the ability to transfer our blood type antigen in our secretions. Actually, that means as a non-secretor your FUT2 mutations can be more problematic. Due to the fact that your good bacteria can’t thrive.  On the other hand, those who are secretors are still at risk, but carry the likelihood of having better protection in terms of their gut immunity or good bacterial production.

People that are considered as non-secretors have a higher susceptibility to any of the following:

  • Norovirus
  • HIV infection
  • Colorectal carcinomas
  • Staphylococcus aureus

FUT2 gene mutations & Leaky Gut (Intestinal permeability)

One of the unfortunate side effects of having mutations in the FUT2 genes is a lack of defenses (immunity). When gut immunity is low, this can cause the lining of the gut to become thin and weak, this is known as leaky gut or intestinal permeability (Which is considered one of the highest reasons for morbity).  The biggest problem with having a leaky gut is that nutrition is absorbed incorrectly. Poor immunity allows for pathogens, bacteria, and viruses to make their way into the bloodstream much more easily.

Once you have this type of situation. The immune system has to deal with many foreign objects entering the body, these foreign object then finding their way to places such as your organs. The immune system then attempts to deal with foreign objects which can lead to an overreaction of the immune system leading to autoimmune disease. Your immune system then attacks the foreign objects which can cause damage to you body including your organs, this is called an autoimmune disease.

FUT2 gene mutations and Autoimmune disease

Right now there are around 100 known autoimmune diseases. An autoimmune disease means that your body’s immune cells become confused and start attacking your own body.  It is important to understand that autoimmune disease is preventable. We know that to get an autoimmune disease you need to have several factors such as:

  • Leaky Gut
  • Any number of other gene mutations
  • An environmental trigger
  • An underlying infection

As you can see having FUT2 gene mutations are very likely to cause a leaky gut, unless it is properly treated. But most of the other factors such as other gene mutations (which most people have). An environmental trigger (which are all around us) and getting an underlying infection. (Which is inevitable if you have leaky gut and or poor immunity). These people cannot afford to risk getting an autoimmune disease.

Treating FUT2 gene mutations

If you have FUT2 gene mutations regardless of them being homozygous or heterozygous, it is extremely important that you treat any active mutations to prevent serious health problems.  The good news is that these mutations are treatable. But it is important to do it right using experienced health practitioners. Those who understand the complicated nature of treating FUT2 gene mutations.

Get a consultation about your FUT2 mutations from the following link  FUT2 Help.

FUT2’s catalytic activity is GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.