FUT2 gene mutations

What is an FUT2 gene?

An Fut2 gene is a gene that gives instructions for making a protein that is involved in the creation of the precursor of the H antigen which is needed to produce fundamental chemicals that produce important enzymes of which are needed to produce a healthy environment for the production of healthy gut flora.

Problem FUT2 genes

FUT2: The 3 major FUT2 genes that seem to cause problems are FUT2 A12190G, FUT2 G12447A and FUT2 G12758A. When these three SNPs are homozygous, these people cannot make H antigen.

If you see any of these 3 FUT2 homozygous mutations you could be in serious trouble:

FUT2 homozygous mutations




Why is H antigen important?

The specificity of the H antigen is determined by the sequence of oligosaccharides. Almost everyone to date who has been diagnosed with ulcerative colitis and Crohn’s disease are homozygous for these three particular mutations. These three FUT2’s also play a huge role in autism and can cause dysfunctional vitamin B12 absorption (Vitamin b12 plasma level quantitative trait locus 1).

FUT2 is involved in protein glycosylation meaning you can lose your ability to properly use your protiens leading to amino acid imbalances.

If you are lacking the ability to produce H antigen in the gut, your probiotics (good bacteria) will not have anything to stick to in the gut which leads to serious gut health problems and is often a risk factor for leaky gut and autoimmune disease.

One of the biggest problems with these gene mutations is overall nutritional disorders as a result of having gut dysbiosis, this is a factor most often overlooked by may health practitioners, put simply if your gut bacteria is well balanced your nutrition will suffer and this leads to literally thousands of other health problems.

Another thing that we see quite often in these homozygouse FUT2’s is hyperoxaluria which can result in lowered ability to defend against cancers. It is nearly next to impossible to heal the gut of these people without properly treating the underlying cause of these active FUT2 gene mutations.

Since poor producers of H antigen already have issues maintaining a healthy gut flora because of their lack of prebiotic production, it is obvious that GMO’d Roundup Ready glyphosate which destroys the shikimate pathway of our gut microbiome is not healthy at all for anyone and especially for these individuals.

Do you have FUT2 symptoms?

FUT2 is an extremely important gene and having a mutation in these genes can lead to literally thousands of health problems, here are just some of the major symptoms to look out for:

  • Any Autoimmune disease
  • Leaky Gut
  • Intestinal permeability
  • Crohn’s disease
  • Ulcerative colitis
  • Eczema or dematitis
  • Prolems with IgG immunity
  • Problems with IgA immunity
  • Autism
  • IBS (Irritable Bowel Syndrome)
  • Pernicious anemia
  • Cardiovascular disease
  • Cancer
  • Neurodegenerative disorders
  • Gut flora imbalances
    • Mouth oversensitive to heat or cold
    • Irritability
    • Anxiety and or tension
    • Lack of energy
    • Constipation
    • Tender or sore muscles
    • Pale skin
    • Tooth decay

    FUT2 Secretors VS Non-Secetors

    Some of us carry the ability to be a “secretor”, that is the ability to secrete our blood type antigen in secretions.  Some of us are “non -secretors” which lack the ability to transfer our blood type antigen in our secretions, this means that as a non-secretor your FUT2 mutations can be more problematic due to the fact that your good bacteria can’t thrive.  Those that are secretors are not out of the woods so to speak but carry the likelihood of having better protection in terms of their immunity.

    Those people that are considered as non-secretors therefore have a higher susceptibility to any of the following:

    • Norovirus
    • HIV infection
    • Colorectal carcinomas
    • Staphylococcus aerus

    FUT2 gene mutations & leaky Gut (Intestinal permeability)

    One of the unfortunate side effects of having mutations in the FUT2 genes is a lack of defenses (immunity) and repair of the gut lining, this causes the lining of the gut to become thin and weak, this is known as leaky gut or intestinal permeability.  The biggest problem with having a leaky gut is that nutrition is absorbed incorrectly, poor immunity allows for pathogens, bacteria, fungi, parasites and viruses to make their way into the blood stream much more easily.

    Once you have this type of situation the immune system has to deal with many foreign objects entering the body and finding their way to places such as your organs, the immune system then attempts to deal with the foreign objects and in doing so depending on your genetic make up along with your particular weaknesses your immune system attacks the foreign objects and while doing so also does damage to your body, this is called auto immune disease.

    FUT2 gene mutations and Autoimmune disease

    Right now there is around 100 known autoimmune diseases, an auto immune disease means that your bod’s immune cells become confused and start attacking you own body.  Its important to understand that autoimmune disease is preventable if you know what your dealing with for example we know that to get an autoimmune disease you need to have several factors working together these include:

    • Leaky gut
    • Any number of other gene mutations
    • An environmental trigger
    • An underlying infection

    As you can see having FUT2 gene mutations are very likely to cause a leaky gut unless it is properly treated, most of the other factors such as other gene mutations (which most people have), an environmental trigger (which are all around us) and getting an underling infection (which is inevitable if you have leaky gut and or poor immunity), these people cannot afford to risk getting an autoimmune disease.

    Treating FUT2 gene mutations

    If you have FUT2 gene mutations regardless of them being homozygous or heterozygous it is extremely important that you treat any active mutations to prevent serious health problems.  The good news is that these mutations are treatable but it’s important to do it right using experienced health practitioners that understand the complicated nature of treating FUT2 gene mutations.

    Get a consultation about your FUT2 mutations from the following link  FUT2 Help.


    FUT2’s catalytic activity is GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.