G6PD gene mutation
G6PD belongs to the Pentose Phosphate Pathway (PPP). This pathway controls the production of NADPH.
What happens when the PPP is not working like it should because of G6PD deficiency?
- Your red blood cells explode
- Your reduced glutathione has oxidative damage
- Your ferritin increases
- CFS/ME due to mitochondrial dysfunction
- Cannot make PAPs
- Cannot make ATP
- Shut off the citric acid cycle
- Shutdown of Phase I liver detox where CYP450’s reside
- Circadian rhythm is compromised
- Redox signaling becomes impaired
- EMF sensitivity sets in
- Higher risk for hemolytic anemia
- Higher risk for POTS (10% of people with POTS are G6PDD)
- Higher risk for lupus
- Higher risk of being injured by a fluoriquinolone
If you have mutations in G6PD you can get tested click here to find out more.