VDR gene mutation

Get tested for VDR gene mutation here.

What are VDR gene mutations?

VDR (Vitamin D Receptor) encodes the nuclear hormone receptor for vitamin D3. Low or low normal vitamin D values are often seen in those with chronic illness and even the general population. Low vitamin D is related to a lot of neurological and immunological conditions. Vitamin D stimulates enzymes that create dopamine.  VDR Tak and VDR Bsm are usually inverse from each other.

So if there is a positive VDR Tak, there would be a negative VDR Bsm. However, this is not always the case.  It has been clinically observed that the body may have trouble tolerating methyl donors with a COMT V158M and a VDR Taq positive status. VDR Taq negative individuals may already have higher levels of dopamine, and combinations of variations COMT and VDR Taq can lead to a wide range of dopamine levels. Those that are VDR Taq positive and COMT negative may have lowest dopamine levels.

Note: Some have pointed out that VDR Taq is reported backwards since majority of medical journals report a different risk allele or use different notation. These arguments are well-founded. Many claims about VDR and methylation are clinical observations. There are no medical studies to support some of the observations.

VDR: When the vitamin D receptor gene is impaired, this can lead to many health problems. Vitamin D hormone is needed to break down into GcMAF which is then needed to attack stealth pathogens, viruses and cancer cells.

Many chronically ill do not get out of the bed to get sulfated D from the sun. Also many chronically ill people are low on GcMAF because they are low on D3 which needs to be sulfated and and broken down into GcMAF.  GcMAF which is one billionth of a gram in the blood is crucial. GcMAF has six attacks on cancer including the cannabinoid pathway.

We also see that many people with viral overloads, autism, cancer and lyme are GcMAF deficient. They may even have D levels close to 100 but they are not sulfating their D3 because of the following:

  • Eating GMO’d Roundup ready foods. Glyphosate converts into glyoxylate. Oxalates share the same transport system as sulfation. I call it oxalates “hogging” up the transport system. This causes poor sulfation of D3 where it cannot sulfate D3 into GcMAF.
  • Zinc is needed to sulfate D3
  • DAO is needed to sulfate D3
  • Lysine is needed to sulfate D3
  • P5P is needed to sulfate D3
  • B6 is needed to sulfate D3

VDR problems / Symptoms

Reduced tolerance for methyl donors in some VDR varients such as:

  • 5-MTHFR
  • Methyl B12
  • Caffeine
  • SAMe (S-Adenosyl methionine)
  • MSM (Methylsulfonylmethane)
  • DMG (Dimethylglycine)
  • TMG (Trimethylglycine) or Betaine
  • CoQ10
  • Melatonin
  • Quercetin
  • Carnitine
  • Theanine
  • Curcumin
  • Green powders / smoothies

VDR & Vitamin D deficiency

Vitamin D deficiency signs  – Joint pain or stiffness, backache, tooth decay, muscle cramps, hair loss, osteoporosis, rickets, seizures, immune deficiency, cancer risk.

Liver Detox – Phase 2

  • VDR VDR:Bsml

Cannaninoid Pathway

  • VDR A48244184C
  • VDR C18167A
  • VDR C37648G
  • VDR C39987A
  • VDR C48238068A
  • VDR C48239675T
  • VDR C48245T
  • VDR C48277713T
  • VDR 48287373A
  • VDR C48296268T
  • VDR C59232T
  • VDR C65594A
  • VDR Fok
  • VDR G14442A
  • VDR G44689A
  • VDR G46489A
  • VDR G48244559A
  • VDR G48262964A
  • VDR G48272743A
  • VDR G48273714A
  • VDR G48285414A
  • VDR G48286015A
  • VDR G48287203A
  • VDR G48293716T
  • VDR G48294131A
  • VDR G64978T
  • VDR S198S
  • VDR T34405C
  • VDR T38809C
  • VDR T4121
  • VDR T416T
  • VDR T47866G
  • VDR T48255411C
  • VDR T48272275C
  • VDR T50459C
  • VDR T66512C
  • VDR T7329C
  • VDR VDR:Bsml


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