Blog Post

Homocysteine & MTHFR

Are you MTHFR?  Have you checked your Homocysteine levels?

Note: Good homocysteine should be between 7 – 8 umol

About Homocysteine

Homocysteine is the chemical that is released into the body as a result from a process called methylation, it’s a normal process as long as the homocysteine your body produces is broken down into other useful, health giving chemicals.  Those with MTHFR gene problems often have homocysteine imbalances either high or low.

When homocysteine becomes elevated this is a warning sign that can result in any of the following:

  • Alzheimers disease
  • Cardiovascular disease mortality
  • Chronic heart failure
  • Heart attack
  • Cerebrovascular and peripheral vascular disease
  • Stroke
  • Cancer
  • Diabetes
  • Death

Knowing your homocysteine  levels can mean the difference between life and death literally.  It’s also important to understand that by simply keeping your homocysteine in check you can dramatically decrease your risk of many of the above health problems by as much as 50%.  This is especially important for those that have MTHFR gene mutations becuase they are often more susceptible to homocysteine imbalances due to their reduced ability to convert folate that is required to make methyltransferase which creates MTHFR that converts to SAMe.

What Causes High Or Elevated Homocysteine?

Homocysteine in the body is produced from processing methionine a natural amino acid, from here normally homocysteine is broken down in two healthy beneficial chemicals called SAMe and glutathione which solves the problem of having high or elevated homocysteine.

Several factors can cause elevated homocysteine, these include:

  • Having the MTHFR gene mutation
  • Poor diet
  • Nutritional problems
  • Stress
  • Genetic inheritance. e.g. Family history of any of the above diseases
  • Folate deficiency
  • Male sex (increased risk)
  • Oestrogen deficiency
  • Excessive alcohol, coffee or tea intake
  • Smoking
  • Lack of exercise
  • Hostility and repressed anger
  • Inflammatory bowel disease (ulcerative colitis, coeliac disease, Chron’s disease)
  • Pregnancy
  • Being vegetarian or vegan
  • High salt intake
  • Hat fat diet with excessive red meat, high fat dairy intake

How Homocysteine Works

In the below diagram you can see the processes that breaks down homocysteine into SAMe and glutathione, any problems with either pathway leads to elevated or high levels of homocysteine…

Homocysteine

As you can see there are several nutrients that work together to make homocysteine work properly.

MTHFR & homocysteine

Those with MTHFR gene variants can have trouble making this process work properly, the obvious problem is that folate is needed to work with vitamin B12, B2 and zinc.  People with MTHFR gene problems have reduced ability to to convert folate making it much harder for this process to work properly.  Further those with MTHFR often have other nutritional problems that use up extra nutrients through over methylation, they run out of resources allowing homocysteine to build up putting themselves at higher risk of those diseases associated of high homocysteine.

But its not all bad news for those with MTHFR gene disorders, the right treatments for MTHFR can improve folate conversion to raise methyltransferase to then produce more MTHFR to convert more SAMe.

Related Posts

gene variant report
Why avoid doing your own gene report

Everyday we receive phone calls and emails from concerned people with serious health problems

MTHFR treatment protocol
The truth about MTHFR treatment protocols

If you have been told that you have a MTHFR gene mutation, polymorphism, variant

MTHFR bad food list
Foods Bad For MTHFR & Poor Methylation

When you have MTHFR you should know if you don't already that eating a

MTHFR & electromagnetic hypersensitivity
MTHFR & Electromagnetic Hypersensitivity

Do you have electromagnetic hypersensitivity from MTHFR? EMF also known as (electro - magnetic - frequency)

Anxiety & MTHFR
Anxiety & MTHFR

If you have experienced anxiety, anxiety attacks or even panic attacks you know only

MTHFR gene mutations and stroke
Can MTHFR gene mutations cause a stroke?

One of the major side affects of having a mthfr gene mutation is the

MTHFR & chronic fatigue syndrome
MTHFR & Chronic Fatigue Syndrome (CFS)

Chronic fatigue syndrome or CFS is a popular term used to describe a condition

What is methylation
What is methylation?

Methylation is one of the most important processes that happens in your brain and body,

MTHFR genes and Schizophrenia
mthfr gene and schizophrenia

Does MTHFR gene mutations cause schizophrenia? Do you have symptoms of schizophrenia & MTHFR? Schizophrenia is

Bipolar disorder & MTHFR gene mutations
Bipolar Disorder & MTHFR

Do you have mood swings? Could it be bipolar disorder? Is your bipolar disorder caused by

MTHFR & ADHD
MTHFR & ADHD

MTHFR also known as methylene tetrahydrofolate reductase is an enzyme in your body that is

mthfr pregnancy
MTHFR pregnancy & what you need to know

If you have mthfr gene mutations its important to understand that when it comes

Methylfolate Side Effects
Methylfolate Side Effects & MTHFR

If you have recently been diagnosed with MTHFR (methylene-tetrahydrofolate reductase) gene mutations, more often

B12 & MTHFR
MTHFR & Vitamin B12

If you have mthfr gene mutations it's vital that you understand the importance of the

MTHFR Depression
MTHFR depression

Is your depression genetic? What is MTHFR depression? MTHFR depression refers to having one or more

MTHFR & weight gain
MTHFR and weight gain

Does MTHFR gene mutation cause weight gain? Many people now being diagnosed with MTHFR gene

MTHFR Genes C677T vs A1298C
MTHFR Genes C677T vs A1298C

MTHFR gene mutations, what's the difference? Many people are getting tested for MTHFR and when