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MTHFR symptoms in women

Oestrogen Dominance (estrogen dominance)

Some women have genes that are prone to estrogen dominance, this hormone which is naturally produced in higher amounts in women can also be problematic when it becomes out of balance. There are a number of genes that control estrogen balance including MTHFR. Women who experience estrogen dominance can have many health problems including those discussed above.

While MTHFR symptoms in women can be any of the MTHFR symptoms on the first MTHFR symptoms tab, it’s important to understand that there are a number of symptoms experienced specifically by women.

Women with MTHFR deficiency can produce very different symptoms that not only affect them as females but also play a serious role in their menstrual cycles, how they detoxify their female organs, how they reproduce, and how their hormones affect their health and mental wellbeing. Hormone imbalances due to MTHFR mutations can lead to mood swings, fertility issues, and overall health problems. There are many disease states that are common in society however MTHFR is most often undiagnosed as the underlying cause for many women.

Women with active MTHFR gene mutations mean a certain % loss of function in methylation, this condition over time means less production of hundreds of complex biochemical processes that the female body needs to maintain good health, including the essential role of folic acid in the folate cycle and reproductive health.

To learn more about methylation imbalances in women click here.

What is MTHFR Gene Mutation?

Definition of MTHFR Gene Mutation

The MTHFR gene mutation is a genetic variation that can significantly impact your health. This mutation affects the body’s ability to convert folate into its active form, which is crucial for numerous bodily functions, including DNA synthesis, repair, and the methylation cycle. The MTHFR gene provides instructions for producing an enzyme called methylenetetrahydrofolate reductase. This enzyme plays a vital role in converting folate into its active form, which is essential for maintaining overall health and well-being.

Prevalence of MTHFR Gene Mutation in Women

The MTHFR gene mutation is surprisingly common, affecting approximately 40-50% of the population. Women with this mutation are particularly susceptible to various health issues, including hormonal imbalances and reproductive health problems. Understanding the prevalence of MTHFR gene mutations can help women recognize and address potential health concerns early on.

Importance of Understanding MTHFR Gene Mutation

Grasping the implications of the MTHFR gene mutation is crucial for women’s health, especially concerning reproductive health and hormone balance. Women with MTHFR gene mutations may face challenges such as difficulty conceiving, miscarriages, and other reproductive health issues. Additionally, these mutations are linked to several health conditions, including polycystic ovary syndrome (PCOS), thyroid disorders, and adrenal fatigue. By understanding the MTHFR gene mutation, women can take proactive steps to manage their health effectively.

Common problems women face with MTHFR gene mutations

Menstrual cycle imbalances

It’s the sad truth these days that when a woman has a complaint about her menstrual cycle it is all too often put into the “It’s normal” too hard basket. Many of the symptoms associated with a menstrual cycle are in truth a red flag that there is something wrong, in other words, this is not “normal”, it is a symptom/s that something is wrong and needs to be fixed. MTHFR deficiency is more often than not part of this problem because MTHFR production plays a large role in how the menstrual cycle works. Follicle stimulating hormone also plays a crucial role in ovarian function and its variations can significantly impact ovarian responsiveness and overall fertility.

Toxic uterus

Part of the problem with having active MTHFR gene mutations is of toxicity. Common problems such as PCOS, fibroids, ovarian cysts, cancer, and many other conditions of the uterus are the result of having a “toxic uterus” when this happens, the environment of the uterus is not clean and often causes menstrual cycle problems along with fertility problems. Having a toxic uterus is also an unhealthy environment for reproduction which can cause problems for pregnancy and some of that toxicity can get passed onto the fetus potentially causing damage to the fetus’s DNA during pregnancy. Ovarian responsiveness can also be affected by genetic variations, particularly MTHFR gene polymorphisms, impacting ovarian activity and hormonal levels.

Infertility

Many women experience infertility and this is not uncommon, while infertility is not exclusively the result of MTHFR gene mutations, having an active MTHFR gene can result in % reduction of a woman’s ability to use her folate, when this happens methylation can’t work properly. It’s important to understand that infertility usually involves several gene mutations and complications associated with those genes that lead to infertility. Genetic factors, including polymorphisms of the MTHFR gene, can influence ovarian response to stimulation and impact fertility outcomes. Click here to learn more about fertility.

Miscarriage

Many women also experience miscarriage and ever reoccurring miscarriages as a result of having an MTHFR gene mutation. It is important to understand however that more often than not MTHFR is not always the biggest reason for the miscarriage or multiple miscarriages. The MTHFR mutation can lead to hormone imbalances, such as estrogen dominance and reduced progesterone levels, affecting reproductive health. Click here to learn more about miscarriage.I had infertility for years, then 3 miscarriages over 4 years, I had never been so discouraged after working with so many doctors and getting nowhere until I found MTHFR gene health on the internet. Within just 1 consultation I learned so much about the problems I was facing and after 6 months of working on my problems with them, I have a healthy baby boy. I can’t thank you enough.K. Riesen – USA

Conditions Associated with MTHFR Gene Mutations in Women

Women with MTHFR gene mutations are at an increased risk of developing various health conditions, including:

  • Polycystic ovary syndrome (PCOS)

  • Thyroid disorders

  • Adrenal fatigue

  • Hormonal imbalances

  • Reproductive health issues, such as infertility and miscarriages

  • High homocysteine levels

  • Methylation cycle disorders

It’s essential for women with MTHFR gene mutations to collaborate with healthcare providers to create personalized treatment plans that cater to their specific health needs. Adopting a healthy diet, making lifestyle modifications, and using targeted supplements can help alleviate symptoms and enhance reproductive health.

Conditions associated to MTHFR gene mutations in women

Conditions Associated with MTHFR Gene Mutations in Women

Methylenetetrahydrofolate reductase (MTHFR) plays a crucial role in ovarian response to fertility treatments, particularly assisted reproductive technology (ART). Specific genetic polymorphisms in the MTHFR gene, such as C677T and A1298C, may influence ovarian responsiveness to hormone treatments and overall reproductive outcomes.

  • Amenorrhea (absence or short lite menstrual cycles)

  • Menorrhagia (heavy menstrual bleeding and or painful period)

  • Problems with menstrual cycles (in general)

  • Toxicity

  • Infertility. Variations in the MTHFR gene may influence the effectiveness of recombinant follicle-stimulating hormone (FSH) in fertility treatments, especially in cases of amenorrhea and other reproductive health issues.

  • Miscarriage or re-occurring miscarriage

  • Estrogen Dominance

  • Anxiety

  • Post natal depression

  • Acne

  • PCOS. MTHFR polymorphisms can affect hormonal regulation and ovarian function, leading to hormonal imbalances and fertility issues.

  • Polycystic ovarian syndrome (PCOS) is associated with MTHFR gene polymorphisms, impacting DNA methylation and folliculogenesis.

  • Ovarian Cysts

  • Fibroids

  • Insomnia

  • Blood clotting

  • Cervical cancer

  • Migraines

  • Weight problems (Obesity)

  • Low or no libido

  • Cervical Dysplasia

  • High blood levels of B12

  • Elevated red cell folate levels

  • Mood swings / Irritability

  • PMT

  • Symptoms of folate deficiency

  • Symptoms of vitamin B12 deficiency

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This page is not designed to provide medical advice or diagnosis.

Russell Browne
Researched and verified by Russell Browne SNHS Dip. (Advanced Nutrition) – specialist expertise in epigenetics, and nutrigenomics (genetic mutation specialist).