Does having an MTHFR gene mutation cause you to get leaky gut syndrome? The short answer is yes it can, but often there are several major factors that ultimately lead to this debilitating disorder.
One of the problems that comes with an active MTHFR gene mutation is a percentage reduction in function of your ability to make active folate. We know that when this happens there can be many symptoms that result. However, one of the symptoms of having reduced folate in terms of having a deficiency is that it can cause the shortening of the villi’s height and thinning of the layers of the gastrointestinal tract. Additionally, the use of synthetic folic acid, which is less bioavailable, can exacerbate these issues by leading to increased homocysteine levels and inflammation. The villi are basically the lining of the intestinal wall, so when they lose their height this makes it easier for you to develop the condition called leaky gut syndrome or intestinal permeability.
Understanding Leaky Gut Syndrome
Leaky gut syndrome, also known as intestinal permeability, occurs when the lining of the small intestine becomes damaged. This damage allows toxins, undigested food particles, and other harmful substances to pass through the gut wall and enter the bloodstream. The result? A range of unpleasant symptoms, including digestive issues, inflammation, and even autoimmune disorders. The connection between leaky gut syndrome and MTHFR gene mutations is significant. MTHFR mutations can impair the body’s ability to produce folate, a crucial nutrient for maintaining the integrity of the gut lining. Without sufficient folate, the gut lining can weaken, leading to increased intestinal permeability and the onset of leaky gut syndrome.
The big problem with intestinal permeability
So just how big of a problem is leaky gut (intestinal permeability)? It’s extremely bad! There are many problems associated with leaky gut, but the major thing you need to know about leaky gut is that among non-communicable diseases, leaky gut is the number one leading cause of disease and even death. One of the big problems with having a leaky gut, apart from the many symptoms it can produce, is that leaky gut can lead to autoimmune disease. Additionally, digestive symptoms linked to gut imbalances and inflammation can provide better insights into overall health than solely focusing on genetic factors related to the MTHFR gene.
So will treating my MTHFR mutations really help prevent leaky gut? Again the short answer is probably not, this is because there are many other genetic mutations that play a significant role in the development of intestinal permeability as well as a long list of other problems that significantly contribute toward developing a leaky gut.
Genetics Involved in Leaky Gut Syndrome
A number of gene mutations have been found to be associated with specific autoimmune diseases and there is usually more than one involved, this is why we can’t just treat the problem assuming MTHFR is the answer. Other gene mutations that are known for being involved in leaky gut syndrome include:
MTHFR – Folate metabolism problems that lead to nutritional deficiencies
HLA – Immune system genes, some of which predisposes you to autoimmune disease from developing a leaky gut
DAO – Mutations in DAO increase histamine levels which aggravates the immune system
FUT – Reduced ability to hold a good balance of good bacteria in the gut
Additionally, the gut microbiota plays a crucial role in maintaining gut health and a balanced immune system. Changes in gut microbiota composition can affect immune responses and brain function, influencing conditions like autism spectrum disorder (ASD).
And any genes involved in and there are many of them.
Gut Bacteria and Immune Function
The gut microbiome, a complex community of microorganisms living in our intestines, plays a vital role in regulating immune function. Beneficial gut bacteria help maintain a balanced immune system and prevent autoimmune disorders. However, when the gut microbiome becomes imbalanced—a condition known as dysbiosis—immune function can be compromised, leading to increased inflammation and a host of health issues. Research indicates that individuals with MTHFR gene mutations are more prone to gut microbiome imbalances. This imbalance can contribute to various health problems, including autoimmune disorders and inflammatory bowel disease. Maintaining a healthy gut microbiome is essential for overall immune health and well-being.
Other Causes of Gut Microbiome Imbalance
Often when it comes to leaky gut syndrome it takes more than just gene mutations to develop the problem, in fact there are many ways this condition can develop.
What’s the real cause of leaky gut?
Leaky gut, also known as intestinal permeability or metabolic endotoxemia is largely the result of living in modern society which is mostly toxic, this combined with the above genetic influences and any of the following is enough to cause the development of a leaky gut:
Alcohol consumption
SIBO (small intestinal bacterial overgrowth)
Nutritional imbalances
Candida infection
Gluten sensitivity
Gut bacterial dysbiosis (the imbalance of good and bad microbes in the gut)
Food allergy or food intolerance’s
High sugar or refined carbohydrate diet
Poor digestion such as a lack of effective digestive enzymes
Use of medical drugs
Intense or chronic stress
Gastrointestinal infections such as parasites, food poisoning or gastroenteritis
Lectins, saponins & alkaloids that are found in some foods such as grains and legumes
Exposure to toxic chemicals
Exposure to heavy metals
Detoxification problems
Gut inflammation, particularly in the gastrointestinal tract, is also prevalent among individuals with autism and can be linked to various health complications, underscoring the complex interplay between gut health and neurodevelopmental issues.
Mitochondria Dysfunction and Oxidative Stress
Mitochondria are the powerhouses of our cells, responsible for producing the energy needed for cellular functions. When mitochondria become dysfunctional, it can lead to a cascade of health problems, including oxidative stress. Oxidative stress occurs when the body’s antioxidant defenses are overwhelmed by free radicals, resulting in cell damage and inflammation. MTHFR gene mutations can exacerbate mitochondria dysfunction and oxidative stress by impairing the body’s ability to produce essential antioxidants and nutrients. This connection underscores the importance of addressing MTHFR mutations to support mitochondrial health and reduce oxidative stress.
Environmental and Epigenetic Factors
Environmental and epigenetic factors play a significant role in the development of health issues associated with MTHFR gene mutations. Diet, lifestyle, and exposure to toxins can all impact gut health and overall well-being. For instance, a diet high in processed foods and low in essential nutrients can lead to poor gut health and increased inflammation. Similarly, exposure to environmental toxins can damage the gut lining and impair immune function. Epigenetic factors, which involve changes in gene expression influenced by environmental factors, also play a crucial role. Understanding and addressing these factors can help mitigate the health risks associated with MTHFR gene mutations.
How do I know if I have leaky gut syndrome?
A good practitioner will be able to have you tested for leaky gut, this will help you establish if you have leaky gut and give you a measure of how advanced it may or may not be. There are many symptoms and conditions associated with having intestinal permeability, below are only a some examples you can look for:
Existing autoimmune disease
Abdominal pain
IBS (irritable bowel syndrome)
Food allergies and sensitivities
Pancreatitis
Aging
Heart failure
Autism
Cirrhosis
Coeliac disease
Inflammatory bowel disease
Inflammatory joint disease
Malabsorption
Rheumatoid arthritis
Schizophrenia
Diabetes
Digestive problems
What can I do to fix my leaky gut?
While having a leaky gut can be distressing, it’s important to know that there is a lot that you can do about it and it’s further really important that you treat the problem seriously. Leaky gut is often caused by a combination of problems and usually there is a genetic component so it’s important that you get help to make sure you are doing everything you can in the right way to solve your specific causes of intestinal permeability.
Having the right practitioner who understands the complexity of genetics and leaky gut could mean the difference between restoring you to good health and or getting a serious disease. If you suspect you have leaky gut or you know you do contact one our professional practitioners for a consultation to get started with a treatment that best suits your needs.
Conclusion
In conclusion, MTHFR gene mutations can significantly impact gut health, immune function, and overall well-being. By understanding the roles of leaky gut syndrome, gut bacteria, mitochondria dysfunction, and environmental and epigenetic factors, individuals with MTHFR gene mutations can make informed lifestyle choices to mitigate potential health risks. Incorporating a healthy diet, lifestyle modifications, and appropriate supplements can improve health outcomes and reduce the risk of associated health problems. Taking proactive steps to support gut health and overall well-being is essential for managing the effects of MTHFR gene mutations.
