Blog Post

Anxiety & MTHFR

If you have experienced anxiety, anxiety attacks or even panic attacks you know only too well that it can be a terrible feeling, even debilitating.  Anxiety is now a very big problem for people all over the world, yet very few people are yet to discover that mthfr gene mutations play a very big part in anxiety & depression disorders.

MTHFR gene mutations are genetic mutations that instruct an important enzyme called MTHFR or Methylene TetraHydroFolate Reductase to down regulate, this causes an inability for the body to use folate from your diet, when this happens many nutritional pathways in the body become disabled or reduced, this causes mthfr symptoms and or conditions associated to mthfr with one of the biggest being anxiety and even panic attacks.

The two main gene mutations that cause anxiety include the C677T and the A1298C genes, each of the gene mutations has their own way of causing you anxiety and often people with more severe cases have both of these mutations at the same time.  Lets take a look at how each of these gene mutations cause you anxiety.

MTHFR anxiety & C677T

The mthfr gene C677T is the mutation predominantly involved in reducing your ability to convert folate from your diet into activated folate, this means that while you have this gene mutation you can end up with a folate or folic acid deficiency and some of the main symptoms of a folate deficiency include anxiety, depression, shortness of breath, difficulty concentrating and poor memory.

Its important to understand that just having low folate levels is enough to cause you anxiety but it doesn’t stop there.  When folate levels becomes depleted because of the gene regulation problem, this causes a chain reaction of other nutritional problems specifically the other B complex group of vitamins and their relationship to minerals, amino acids and essential fatty acids.

B complex group of vitamins & anxiety

Vitamin B1 – When this vitamin becomes deficient lactic acid builds up in your body which leads to lactic acidosis, this condition leads to anxiety and triggers panic attacks.

Vitamin B2 – When this vitamin becomes deficient it causes a reduction in a coenzyme that makes vitamin B6 work properly as an antidepressant and vitamin B3 cannot be made properly from the amino acid tryptophan which leads to depression.

Vitamin B3 – When this vitamin becomes deficient it causes anxiety and depression.

Vitamin B5 – When this vitamin becomes deficient it causes fatigue with anxiety, restlessness and irritability.

Vitamin B6 – When this vitamin becomes deficient it causes depression, nervousness, irritability and fatigue.

Vitamin B12 – When this vitamin becomes deficient it causes irritability, anxiety or tension, shortness of breath and heart palpitations

As you can see when you have the C667T gene mutation you lose your ability to use folate properly and because folate works with the other B vitamins they also become unusable which leads to anxiety, depression and even panic attacks.  Taking folate or folic acid and B vitamin supplements also becomes ineffective due to the lack of mthfr enzyme needed to make that conversion.

MTHFR anxiety & A1298C

The mthfr gene A1298C is the mutation predominantly involved in reducing your ability to produce neurotransmitters that keep you happy and calm.  Neurotransmitters such as serotonin and dopamine keep you calm, happy and motivated, when you have the A1298C gene your production of these vital neurotransmitters is reduced or becomes unbalanced, this then causes you to feel low, worried, depressed and or anxious.

Is MTHFR causing your anxiety?

Over 50% of society has one or more mthfr gene mutations, a simple mthfr home test can tell you if you have one of the genes and specific anxiety treatments go a long way to helping you overcome your anxiety, depression & or panic attacks.

MTHFR gene mutation affects almost every area of your body, that means it can affect your organs, your brain and nervous system, this is why it can easily cause anxiety.  MTHFR causes many mental health problems that are strongly associated to anxiety disorder such as:

  • Depression
  • Anxiety
  • Low self esteem
  • Mood swings
  • Bipolar disorder
  • ADD / ADHD
  • Suicidal thoughts
  • Obsessive compulsive disorder
  • Oppositional defiant disorder
  • Learning difficulties
  • Addictive behavior
  • Schizophrenia

How to resolve anxiety with MTHFR

Often people have experienced anxiety for many years of their lives and it can be difficult for them to imagine life without anxiety.  Once you discover that your anxiety is coming from mthfr gene problems there is good news, correcting nutritional imbalances the right way by supporting the gene mutation is very successful at resolving anxiety.  Get yourself tested for the mthfr  gene mutations and seek professional treatments that can greatly help boost your resistance to anxiety.

Other gene mutations and anxiety

There are many gene mutations that can cause anxiety other than or in conjunction with mthfr, if you have anxiety and have tested for mthfr and didn’t find a positive result, it’s recommended that you get tested for additional gene mutations that cause anxiety.  Some of the more common genes that cause anxiety include:


Did you have any questions about the MTHFR & anxiety?  Contact us here.


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