Blog Post

MTHFR pregnancy & what you need to know

If you have mthfr gene mutations its important to understand that when it comes to getting pregnant, being prepared could mean the difference between success or failure. Being prepared could also mean the difference between having a healthy baby and having a baby with serious health problems.

And not being prepared properly for pregnancy with a mthfr gene mutation can even mean the difference between life and death of your unborn child in terms of miscarriages which are very common for those with the gene mutation.

Key considerations with MTHFR pregnancy

When it comes to successful pregnancy and mthfr gene problems there are some key considerations, things that are important to know if you want to have not only a successful pregnancy but also have a health baby.  Here are the key points you should know about mthfr & pregnancy:

  • Mum represents 50% of the DNA that gets passed on to the baby
  • Dad represents 50% of the DNA that gets passed on to the baby
  • Mun & dad pass on their DNA and any other health problems they may have, which should be resolved before considering pregnancy to benefit the quality of life of the child

This means that both parties are responsible for passing on good health to the child.  If mum and or dad have MTHFR gene mutations, these get passed on to the child through their DNA contribution respectively.  It also means that if either person has other health problems this can cause further problems with getting pregnant and or passing on those health problems to their unborn baby and or can cause miscarriage.

People with MTHFR gene mutations have a reduced ability to metabolize folate which increases the risk of folate related pregnancy problems such as:

  • Neural tube defects (due to low folate and high homocysteine)
  • Low quality sperm and DNA issues with sperm
  • Thrombophilla (clotting disorder)
  • Autism in the child (80-85% are MTHFR)
  • ADD/ADHD behavioral issues in the child
  • Allergies (high histamine)
  • Low birth weight
  • Placenta gets clots and starves the child who dies or causes miscarriage

With pregnancy there are periods of rapid growth for the fetus, this requires an increased need for healthy DNA production, this process is largely governed by adequate folate levels which those with mthfr gene problems have more trouble producing thus, their need for folate metabolism must be increased prior to getting pregnant to be able to supply the right amount of DNA production to have a successful pregnancy.

Why MTHFR gene mutations causes pregnancy problems & miscarriages

MTHFR gene mutations are complicated in nature and each person no matter their gene mutation has their own set of underlying health problems, this means that there can be multiple reasons for having a miscarriage, here are the main problems:

  • Lack of folate to help the baby grow and develop because of MTHFR
  • Lack of preparation time pre pregnancy to support good DNA
  • Homocysteine imbalances
  • Lack of proper nutrition
  • Build up of toxins
  • Thyroid issues
  • Genes that affect the proper clearing of hormones allowing estrogen to build up.  (estrogen dominance)
  • Hormonal imbalances
  • Particularly low progesterone
  • PCOS (ploycystic overy syndrome)
  • Endometriosis
  • No ovulation
  • Low healthy cervical fluid
  • Endometrium not healthy (the inner mucous membrane of the mammalian uterus)
  • Not enough follicles

Important MTHFR pregnancy points

  • The DNA health and nutrition stores are passed onto the fetus upon conception, along with the MTHFR gene mutation.
  • Health of both male and female at conception will determine how MTHFR is impacting your body and to what degree this will then impact the baby.
  • Well controlled or managed MTHFR problems will affect the health of a fetus, supporting the process through preconception will dramatically increase success.
  • What you do for your unborn child before pregnancy, during pregnancy and post pregnancy  can affect 4 generations of DNA problems.
  • If you have good folate levels before you conceive, there will be less congenital anomalies and overall problems.
  • Folate as (L-5MTHF) supplements during preconception can reduce anomalies including neural tube defects but is not always advisable for some.  Methylfolate supplements can cause harm for some mthfr gene problem.
  • If your B12 levels are low this prevents the use of folate.  Other vitamins, minerals, amino acids and essential fatty acids also work with B12 and folate, these need to be optimal for successful pregnancy.

MTHFR gene mutations in male & female fertility

If men or women with mthfr gene mutations are left unsupported nutritionally, the MTHFR gene reduces the amount of methyl groups available for use throughout the body.  Methyl groups are needed in the male and female body for many reasons, all of which are needed for to create the proper environment for a healthy pregnancy such as:

  • To synthesize choline thats needed for optimal brain health in the unborn child
  • To balance neurotransmitters needed for healthy brain, mood, sleep & digestion
  • To keep inflammation in check
  • Helps keep the immune system strong
  • To metabolize toxins and hormones (such as estrogen dominance)
  • Crucial for DNA synthesis

MTHFR pregnancy & homocysteine

People with mthfr gene problems often have problems with homocysteine balance which is a crucial factor in pregnancy, high homocysteine for example can cause any of the following that can prevent pregnancy and or cause miscarriage:

  • Lower ovarian reserves
  • A diminished response to follicular stimulation
  • Reduced chance of live birth after IVF
  • Egg death
  • Complications with egg development
  • Complications with preparation of the endometrium for implantation

What are the main risks for C677T mutations and pregnancy?

  • Pre-eclampsia, specally in caucasian and east asian populations
  • Recurrent pregnancy loss (RPL)
  • Congenital heart defects
  • Down’s syndrome
  • Thombophilia (related to MTHFR gene  mutations – hypertension, recurrent abortions and intra-uterine growth retardation)
  • Neural tube defects
  • Autism

What are the main risks for A1298C mutations and pregnancy?

  • Thombophilia (related to MTHFR gene  mutations – hypertention, recurrent abortions and intra-uterine growth retardation when associated with C667T)
  • Problems with neurotransmitter function
  • Depression
  • Anxiety
  • Mood swings
  • Emotional problems

How to be successful with MTHFR gene mutations & pregnancy

Having a successful pregnancy with the MTHFR gene mutation is all about being prepared and doing the right thing by your unborn child.  When you and your partner are healthy and you’ve taken the steps to ensure that you pass on the best of your DNA and the best of your own health, this can result in a successful pregnancy.

Common Supplements to assist with MTHFR pregnancy

It’s important to understand that gene mutations take on a life of their own when it comes to supplements, for some people with the gene problem certain supplements work great to support pregnancy while others don’t do as well and need different supplements in right order, in the right amounts to solve underlying nutritional problems.  Common supplements used to support mthfr pregnancy include:

  • Methyl-folate (under the supervision of a mthfr practitioner)
  • Vitamin B12 (In certain forms depending on your gene mutation, avoid common B12 cyanocobalamin for mthfr gene problems)
  • Vitamin B6 (may need active forms)
  • Folinic acid (avoid folic acid)
  • Magnesium
  • Calcium
  • Iodine
  • alpha lipoic acid
  • Co Q10
  • Vitamin E
  • Phosphatidylcholine
  • Other minerals that are deficient according to your hair mineral analysis.

Need help with MTHFR pregnancy?

We are here to help!  Contact MTHFR gene health to get started on the right way to get pregnant.

Did you have any questions about the MTHFR & pregnancy?  Contact us here.

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